Blastocyst Transfer

Blastocyst transfer is a pivotal procedure in assisted reproductive technology (ART), particularly in the vitro fertilization (IVF). It involves transferring embryos at the blastocyst stage—typically five to six days after fertilisation—into the uterus. This approach closely mimics natural conception, where the embryo reaches the uterus at this developmental phase, potentially enhancing implantation success rates.

Understanding the Blastocyst Stage

A blastocyst is a more advanced embryo, having developed for five to six days post-fertilisation. At this stage, the embryo comprises approximately 100-200 cells and has differentiated into two distinct cell types:

  • Inner Cell Mass (ICM): This group of cells will develop into the fetus.
  • Trophectoderm: These cells will form the placenta and other supporting tissues essential for fetal development.

The blastocyst also contains a fluid-filled cavity called the blastocoel. 

Advantages of Blastocyst Transfer

Transferring embryos at the blastocyst stage offers several benefits:

Enhanced Selection

Culturing embryos to the blastocyst stage allows embryologists to better assess their development and select those with the highest implantation potential.

Improved Synchronisation

The uterine environment is naturally more receptive to embryos at the blastocyst stage, aligning with the typical timing of embryo arrival in natural conception.

Reduced Multiple Pregnancies

By selecting high-quality blastocysts, clinicians can transfer fewer embryos, thereby decreasing the risk of multiple pregnancies while maintaining high success rates.

blastocyst implntation

Procedure of Blastocyst Transfer

The blastocyst transfer process involves several key steps:

  • Ovarian Stimulation: Hormonal medications stimulate the ovaries to produce multiple eggs.
  • Egg Retrieval: Mature eggs are collected from the ovaries using a minor surgical procedure.
  • Fertilisation: Retrieved eggs are fertilised with sperm in the laboratory, leading to embryo development.
  • Embryo Culture: Embryos are cultured for five to six days until they reach the blastocyst stage.
  • Embryo Transfer: Selected blastocyst(s) are transferred into the uterus using a fine catheter, a procedure typically guided by ultrasound to ensure precise placement.

Success Rates and Considerations

While blastocyst transfer has been associated with higher implantation and pregnancy rates, it’s important to note that not all embryos will develop to the blastocyst stage. Therefore, the decision to proceed with blastocyst transfer should be individualised, considering factors such as the number and quality of embryos, as well as the patient’s specific circumstances. 

Why Choose Dr. Kamaraj Hospital ?

At Dr. Kamaraj Hospital, we are committed to providing personalized and compassionate care in the field of reproductive medicine. Our team of experienced fertility specialists utilizes state-of-the-art technology to optimize outcomes for our patients. We offer comprehensive services, including blastocyst transfer, tailored to meet each individual's unique needs on their journey to parenthood.

You can count on our men's health specialists for the support and treatment you need for conditions like varicoceles. We are committed to the highest quality of treatment to help you lead a healthy life.

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FAQs

What is the difference between blastocyst transfer and cleavage-stage transfer?
Blastocyst transfer involves transferring embryos at the five to six-day stage of development, whereas cleavage-stage transfer occurs at the two to three-day stage. Blastocyst transfer allows for better selection of viable embryos and may improve implantation rates.
While blastocyst transfer can enhance pregnancy rates, not all embryos reach the blastocyst stage, which may result in fewer embryos available for transfer. Additionally, there is a slightly increased risk of monozygotic (identical) twinning.
The number of blastocysts transferred depends on various factors, including the patient’s age, embryo quality, and specific clinical circumstances. In many cases, a single high-quality blastocyst is transferred to minimize the risk of multiple pregnancies.
Yes, surplus high-quality blastocysts can be cryopreserved (frozen) for future use, allowing for additional transfer attempts without the need for repeated ovarian stimulation and egg retrieval procedures.
Success rates are influenced by factors such as the woman’s age, embryo quality, uterine receptivity, and overall health. A thorough evaluation by fertility specialists can help determine the most appropriate treatment plan.

Meet Our Doctor

Best Sexologist in Chennai Dr. T Kamaraj

Dr. T. Kamaraj

Sexologist & Male Infertility Specialist

MBBS degree and advanced qualifications in obstetrics and gynaecology
Infertility Specialist Dr. J S Jeyarani Kamaraj

Dr. J. S. Jeyarani Kamaraj

Infertility Specialist

MBBS degree and advanced qualifications in obstetrics and genecology, including an MD and a Diploma in Gynecology and Obstetrics (DGO)